| 货号 | 2722/1 |
| 别名 | Chromogranin A344-364 |
| 供应商 | Tocris |
| 生物活性 | Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release. Also stimulates mast cell release of histamine via a separate mechanism. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 2425.84 |
| 分子式 | C107H173N37O26S |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 142211-96-9 |
| 序列号 | RSMRLSFRARGYGFRGPGLQL |
| 参考文献 | Krugeret al (2003) Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides. Regul.Peptides 11429. Mahataet al (2000) Primary structure and function of the catecholamine release inhibitory peptide catestatin (Chromogranin A344-364): identification of amino acid residues crucial for activity. Mol.Endocrinol. 14 1525. PMID: 11043569. Mahataet al (1997) Novel autocrine feedback control of catecholamine release. J.Clin.Invest. 100 1623. PMID: 9294131. |