| 货号 | 1844/1 |
| 供应商 | Tocris |
| 生物活性 | Somatostatin receptor ligand (Ki values are 142, > 1000, 10.8, 16.6 and 5.7 nM for human cloned sst1 - 5 receptors respectively). Behaves as an antagonist on SRIF14-induced [35S]-GTPγS binding at sst3 and sst5 receptors (PKB values are 6.33 and 5.84 respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1232.49 |
| 分子式 | C71H81N11O9 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in 20% acetonitrile / water |
| CAS号 | 150155-61-6 |
| 序列号 | FFYWKVFX (Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, X = D-Nal & C-terminal amide) |
| 参考文献 | Siehler and Hoyer (1999) Characterisation of human recombinant somatostatin receptors. Modulation of GTPgammaS binding. Naunyn Schmiedebergs Arch.Pharmacol. 360 500. PMID: 10598789. Wilkinsonet al (1996) Potent antagonism by BIM-23056 at the human recombinant somatostatin sst5 receptor. Br.J.Pharmacol. 118 445. PMID: 8762063. Patel and Srikant (1994) Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology 135 2814. PMID: 7988476. Raynoret al (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. Mol.Pharmacol. 43 838. PMID: 8100350. |