| 货号 | 2416/10 |
| 别名 | N8-(3-Chloro-4-fluorophenyl)-N2-(1- |
| 供应商 | Tocris |
| 生物活性 | Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). Oral administration inhibits growth of established human xenografts in athymic mice. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 460.77 |
| 分子式 | C18H19ClFN7.2HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 50 mM in DMSO |
| CAS号 | 196612-93-8 |
| 参考文献 | Solcaet al (2004) Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J.Pharmacol.Exp.Ther. 311 502. PMID: 15199094. Dittrichet al (2002) Phase I and pharmacokinetic study of BIBX1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration. Eur.J.Cancer 38 1072. PMID: 12008195. |