| 货号 | 4676/10 |
| 别名 | (2S)-2-(3-Aminopropyl)-5-(2,5-diflu |
| 供应商 | Tocris |
| 生物活性 | Potent kinesin spindle protein (KSP) inhibitor (IC50 = 6 nM); selective for KSP over >250 other receptors and kinases at a concentration of 10 μM. Displays robust antitumor activity in bortezomib-resistant xenografts either alone or in combination with bortezomib. Induces degradation of Mcl-1; exhibits comparable cytotoxic activity to taxol (Cat. No. 1097) in epithelial ovarian cancer cells. Active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 420.48 |
| 分子式 | C20H22F2N4 |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO and to 75 mM in ethanol |
| 参考文献 | Tunquistet al (2010) Mcl-1 stability determines mitotic cell fate of human multiple myeloma tumor cells treated with the kinesin spindle protein inhibitor ARRY-520. Mol.Cancer.Ther. 9 2046. PMID: 20571074. Kimet al (2009) KSP inhibitor ARRY-520 as a substitute for Paclitaxel in type I ovarian cancer cells. J.Transl.Med. 7 63. PMID: 19619321. Woessneret al (2009) ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models. Anticancer Res. 29 4373. PMID: 20032381. |