| 货号 | 2511/5 |
| 别名 | N-(1-Hydroxy-2-naphthoyl)-L-arginyl |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of mast cell tryptase (Ki = 7.1 μM) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 440.5 |
| 分子式 | C22H28N6O4 |
| 可溶性/溶解性 | Soluble to 5 mg/ml in 20% ethanol / water |
| CAS号 | 178925-65-0 |
| 序列号 | N-(1-Hydroxy-2-naphthoyl)-L-ar |
| 参考文献 | Heet al (2004) Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. J.Pharmacol.Exp.Ther. 309 119. PMID: 14722328. Barrioset al (1998) Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 63 2295. PMID: 9877219. Heet al (1998) A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase. J.Pharmacol.Exp.Ther. 286 289. PMID: 9655871. Numerofet al (1997) Tryptase inhibitors: a novel class of anti-inflammatory drugs. Exp.Opin.Invest.Drugs. 6811. |