| 货号 | 1845/500U |
| 供应商 | Tocris |
| 生物活性 | Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. Anti-inflammatory. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 3089.46 |
| 分子式 | C141H210N32O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in PBS |
| 序列号 | AMVSEFLKQAWFIENEEQEYVQTVK (Modifications: Ala-1 = N-terminal Ac) |
| 参考文献 | Leoniet al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J.Clin.Invest. 125 1215. PMID: 25664854. Perretti and Gavins (2003) Annexin 1: an endogenous anti-inflammatory protein. News Physiol.Sci. 18 60. PMID: 12644621. Limet al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc.Natl.Acad.Sci.U.S.A. 95 14535. PMID: 9826735. Perrettiet al (1993) Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody. J.Immunol. 151 4306. PMID: 8409403. |