| 货号 | 1590/1 |
| 供应商 | Tocris |
| 生物活性 | Highly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ,δandκ receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1909.18 |
| 分子式 | C82H137N31O22 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 236098-40-1 |
| 序列号 | FGGFTGARKSARKRKNQ |
| 参考文献 | Caloet al (2002) Pharmacological profile of nociceptin/orphanin FQ receptors. Clin.Exp.Pharmacol.Physiol. 29 223. PMID: 11906488. Rizziet al (2002) [Arg14,Lys15]Nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J.Pharmacol.Exp.Ther. 300 57. PMID: 11752097. Okadaet al (2000) Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem.Biophys.Res.Commun. 278 493. PMID: 11097863. |