| 货号 | 22093-1mg |
| 描述 | Rapamycin-d3 (Item No. 22093) contains three deuterium atoms at the methyl position. It is intended for use as an internal standard for the quantification of rapamycin (Item No. 13346) by GC- or LC-MS. Rapamycin interacts with the cytosolic FK-binding protein 12 (FKBP12) to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1 (mTORC1).1 Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.2,3,4 |
| 别名 | Sirolimus-d3; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kay, J.E.,Kromwel, L.,Doe, S.E.A., et al. Inhibition of T and B lymphocyte proliferation by rapamycin. Immunology 72(4), 544-549 (1991). 2.Akcakanat, A.,Zhang, L.,Tsavachidis, S., et al. The rapamycin-regulated gene expression signature determines prognosis for breast cancer. Molecular Cancer 8(75), (2009). 3.Zhang, Y.,Xu, S.,Lin, J., et al. mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo. Breast Cancer Res. Treat. 136(2), 379-388 (2012). 4.Balgi, A.D.,Fonseca, B.D.,Donohue, E., et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4(9), 1-15 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d3) |
| 计算分子量 | 917.2 |
| 分子式 | C51H76D3NO13 |
| CAS号 | 392711-19-2 |
| 稳定性 | ≥ 2 years |
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