Toll-Like Receptor 7 Ligand II
货号：
17228-1mg 基本售价：
3332.0 元 规格：
1 mg
产品信息
概述| 货号 | 17228-1mg |
| 描述 | A potential treatment for hepatitis C virus (HCV) is to induce immune cell-derived interferon (IFN) production using synthetic agonists of toll-like receptor 7 (TLR7). TLR7 ligand II is an orally bioavailable 8-hydroxyadenine analog that induces IFN production by binding to TLR7 on immune cells.1,2 It induces IFNα in human peripheral blood mononuclear cells with an EC50 value of 0.14 µM.2 At 10 µM, TLR7 ligand II was shown to reduce HCV levels by 60% in 24 hours in the human hepatocyte cell line Huh7, which carries a HCV replicon.3 It induces IFN in mice with a minimal effective dose of approximately 0.03 mg/kg, making it approximately 100-fold more potent than imiquimod (Item No. 14956).1 |
| 别名 | CL 087;SM-360320;TLR7 Ligand II;1V136; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kurimoto, A.,Ogino, T.,Ichii, S., et al. Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities. Bioor.Med.Chem. 12, 1091-1099 (2004).
2.Jin, G.,Wu, C.C.N.,Tawatao, R.I., et al. Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent toll-like receptor 7 agonists. Bioor.Med.Chem. 16, 4559-4563 (2006).
3.Lee, J.,Wu, C.C.N.,Lee, K.J., et al. Activation of anti-hepatitis C virus responses via toll-like receptor 7. Proceedings of the National Academy of Sciences of the United States of America 103(6), 1828-1833 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 315.3 |
| 分子式 | C15H17N5O3 |
| CAS号 | 226907-52-4 |
| 稳定性 | ≥ 2 years |
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