| 货号 | 10169-50ug |
| 描述 | Arachidonoyl ethanolamide (AEA; Item No. 90050) was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as THC.1,2 Since that time, a number of related endocannabinoids have been isolated, most notably 2-arachidonoyl glycerol (Item No. 62160).2 Lipoxygenases, especially rabbit reticulocyte and soybean 15-lipoxygenases, actively convert endocannabinoids to their 15(S)-hydroperoxy and hydroxy metabolites.3 15(S)-HETE ethanolamide is less potent than AEA at the CB1 receptor (Ki of 600 versus 90 nM). 15(S)-HETE ethanolamide also inhibits fatty acid amide hydrolase.4 |
| 别名 | 15(S)-HAEA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Devane, W.A.,Hanus, L.,Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946-1949 (1992). 2.Felder, C.C.,Briley, E.M.,Axelrod, J., et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proceedings of the National Academy of Sciences of the United States of America 90, 7656-7660 (1993). 3.Ueda, N.,Yamamoto, K.,Kurahashi, Y., et al. Oxygenation of arachidonylethanolamide (anandamide) by lipoxygenases. Advances in Prostaglandin, Thromboxane, and Leukotriene Research 23, 163-165 (1995). 4.van der Stelt, M.,van Kuik, A.,Bari, M., et al. Oxygenated metabolites of anandamide and 2-arachidonoylgycerol: Conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase. Journal of Medicinal Chemistry 45, 3709-3720 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 363.5 |
| 分子式 | C22H37NO3 |
| CAS号 | 161744-53-2 |
| 稳定性 | ≥ 1 year |
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