Protein Phosphatase 2A C subunit (human recombinant; L309 deletion)
货号：
10011237-10ug 基本售价：
3290.0 元 规格：
10 ug
产品信息
概述| 货号 | 10011237-10ug |
| 描述 | Reversible protein phosphorylation is a fundamental regulatory mechanism in all aspects of biology. Protein phosphatase 2A (PP2A) is a divalent cation-independent protein serine/threonine phosphatase involved in regulating numerous cellular processes including the cell cycle, growth and differentiation and is also thought to be a potential tumor suppressor.1 PP2A is a hetrotrimeric protein containing a 65 kDa scaffolding A subunit, a regulatory B subunit and a 36 kDa catalytic C subunit.2 The recombinant PP2A catalytic subunit has the characteristic properties of Type 2A phosphatases and is highly sensitive to okadaic acid and microcystins.3 The provided preparation of the catalytic subunit of PP2A is useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and to evaluate the effects of test substances on the activity of the phosphatase. |
| 别名 | PP2A Cα;PP2A L309;PP2A Δ309; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Perrotti, D. and Neviani, P. Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias. Cancer Metastasis Reviews (2008).
2.Xing, Y.,Xu, Y.,Chen, Y., et al. Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Cell 127, 341-353 (2006).
3.Ikehara, T.,Shinjo, F.,Ikehara, S., et al. Baculovirus expression, purification, and characterization of human protein phosphatase 2A catalytic subunits α and β. Protein Expression and Purification 45(1), 150-156 (2006).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 稳定性 | ≥ 6 months |
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