| 货号 | 11208-1mg |
| 描述 | KRN 7000 is a potent synthetic α-galactosylceramide, which, in association with the antigen-presenting CD1d protein, activates NKT immune cells.1,2 As these cells have important roles in the rejection of malignant tumors and in the regulation of several autoimmune diseases, KRN 7000 has activity in many diseases, including cancer, lupus, diabetes, malaria, and tuberculosis.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Van Der Vliet, H.J.J.,Nishi, N.,Koezuka, Y., et al. Effects of α-galactosylceramide (KRN7000), interleukin-12 and interleukin-7 on phenotype and cytokine profile of human Vα24+ Vβ11+ T cells. Immunology 98, 557-563 (1999). 2.Nicol, A.,Nieda, M.,Koezuka, Y., et al. Human invariant Vα24+ natural killer T cells activated by α-galactosylceramide (KRN7000) have cytotoxic anti-tumour activity through mechanisms distinct from T cells and natural killer cells. Immunology 99, 229-234 (2000). 3.Morita, M.,Motoki, K.,Akimoto, K., et al. Structure-activity relationship of α-galactosylceramides against B16-bearing mice. Journal of Medicinal Chemistry 38, 2176-2187 (1995). 4.Nakagawa, R.,Motoki, K.,Ueno, H., et al. Treatment of hepatic metastasis of the Colon26 adenocarcinoma with an α-galactosylceramide, KRN7000. Cancer Research 58, 1202-1207 (1998). 5.Banchet-Cadeddu, A.,Hénon, E.,Dauchez, M., et al. The stimulating adventure of KRN 7000. Organic & Biomolecular Chemistry 9, 3080-3104 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥96% |
| 计算分子量 | 858.3 |
| 分子式 | C50H99NO9 |
| CAS号 | 158021-47-7 |
| 稳定性 | ≥ 1 year |
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