UNC-2170
货号：
14120 基本售价：
3262.5 元 规格：
25 mg
产品信息
概述| 货号 | 14120 |
| 描述 | The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-stranded DNA breaks. UNC-2170, identified by screening, was found to be a µM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain (ref 1). |
| 别名 | 3-Bromo-N-(3-(ter-butylamino)propyl)benzamide, hydrochloride |
性能| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 3 months. |
| 纯度 | MP = 162-164°C >98% (TLC); NMR (Conforms) |
| 计算分子量 | 349.7 |
| 分子式 | C14H21BrN2O • HCl |
| CAS号 | 1648707-58-7 |
| 外观 | White powder. May be dissolved in DMSO (40 mg/ml); or water (50 mg/ml). |
| 参考文献 | 1. MT Perfetti et al. ACS Chem. Biol. 2015, 10:1072
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