| 货号 | 5915/10 |
| 别名 | 1,5-Dihydro-6-[(1R)-1-(3-phenoxy-1- |
| 供应商 | Tocris |
| 生物活性 | Potent PDE9 inhibitor (IC50 = 22 nM). Also exhibits a high affinity for cGMP (Km = ~170 nM). Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 395.45 |
| 分子式 | C21H25N5O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl with gentle warming |
| 参考文献 | Leeet al (2015) Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease. Nature 519 472. PMID: 25799991. Claffeyet al (2012) Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J.Med.Chem. 55 9055. PMID: 23025719. Kleimanet al (2012) Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. J.Pharmacol.Exp.Ther. 341 396. PMID: 22328573. |