| 货号 | 1803/10 |
| 别名 | 2-(1H-Indol-3-ylcarbonyl)-4-thiazol |
| 供应商 | Tocris |
| 生物活性 | Endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF-β-induced human myofibroblast differentiation. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 286.3 |
| 分子式 | C14H10N2O3S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 448906-42-1 |
| 参考文献 | Chenget al (2015) Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Nat.Commun. 6 7209. PMID: 26059097. Wanget al (2013) An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells. Cancer Lett. 340 63. PMID: 23851185. Lehmannet al (2011) The aryl hydrocarbon receptor ligand ITE inhibits TGF |