| 货号 | 2253/1 |
| 别名 | 5,6,7,13-Tetrahydro-13-methyl-5-oxo |
| 供应商 | Tocris |
| 生物活性 | Potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ(IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 378.43 |
| 分子式 | C24H18N4O |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 136194-77-9 |
| 参考文献 | Stolzet al (2009) Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole discovered by cellular screening efficiently kills cancer cells. Cancer Res. 69 3874. PMID: 19366805. Grandageet al (2006) Go6976 is a potent inhibitor of JAK2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells. Br.J.Haematol. 135 303. PMID: 16956345. Behrenset al (1999) Go 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase. J.Neurochem. 72 919. PMID: 10037462. Renneckeet al (1996) Immunological demonstration of protein kinase Cμ in murine tissues and various cell lines. Eur.J.Biochem. 242 428. PMID: 8973662. Martiny-Baronet al (1993) Selective inhibition of protein kinase C isozymes by the indolocarbazole G |