| 货号 | 3555/100U |
| 别名 | Calcitonin receptor-stimulating peptide-1 |
| 供应商 | Tocris |
| 生物活性 | Endogenous central calcitonin (CT) receptor agonist that stimulates cAMP formation at a potency 350-fold greater than CT (ED50 values are 0.2 and 71 nM respectively). Displays no activity at calcitonin-gene related peptide (CGRP) and adrenomedullin receptors. Inhibits formation of multinuclear osteoclasts with similar efficacy to CT in vitro. Suppresses food intake and increases body temperature in free-feeding rats, and significantly decreases plasma calcium levels in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4098.88 |
| 分子式 | C175H294N54O |
| 可溶性/溶解性 | Soluble to 0.50 mg/ml in 10% acetonitrile / water |
| 序列号 | SCNTATCMTHRLVGLLSRSGSMVRSNLLPT (Modifications: Disulfide bridge between 2 - 7, Gly-38 = C-terminal amide) |
| 参考文献 | Notoyaet al (2007) A novel member of the calcitonin gene-related peptide family, calcitonin receptor-stimulating peptide, inhibits the formation and activity of osteoclasts. Eur.J.Pharmacol. 560 234. PMID: 17328890. Sawadaet al (2006) Central effects of calcitonin receptor-stimulating peptide-1 on energy homeostasis in rats. Endocrinology 147 2043. PMID: 16410305. Katafuchiet al (2003) Calcitonin receptor-stimulating peptide, a new member of the calcitonin gene-related peptide family. Its isolation from porcine brain, structure, tissue distribution, and biological activity. J.Biol.Chem. 278 12046. PMID: 12556539. |