| 货号 | 16310-25ug |
| 描述 | 8,12-iso-iPF2α-VI is an isoprostane produced by non-enzymatic, free radical-induced peroxidative damage to membrane lipids. It is the most abundant isoprostane product that is formed during lipid peroxidation and is used as a biomarker for oxidative stress.18,12-iso-iPF2α-VI is detected after CCl4-induced oxidative damage to hepatic tissue and has been found elevated in the urine, blood, and cerebrospinal fluid of patients with Alzheimer’s disease.2,3,4 |
| 别名 | 12-iso-5(R),6E,14Z-Prostaglandin F2α; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Li, H.,Lawson, J.A.,Reilly, M., et al. Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F2-isoprostanes in human urine. Proceedings of the National Academy of Sciences of the United States of America 96(23), 13381-13386 (1999). 2.Sicilia, T.,Mally, A.,Schauer, U., et al. LC-MS/MS methods for the detection of isoprostanes (iPF2α-III and 8,12-iso-iPF2α-VI) as biomarkers of CCI4-induced oxidative damage to hepatic tissue. Journal of Chromatography B 861, 48-55 (2008). 3.Praticò, D.,Clark, C.M.,Liun, F., et al. Increase of brain oxidative stress in mild cognitive impairment. A possible predictor of Alzheimer disease. Archives of Neurology 59, 972-976 (2002). 4.Shaw, L.M.,Korecka, M.,Clark, C.M., et al. Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics. Nature Reviews.Drug Discovery 6, 295-303 (2007). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 354.5 |
| 分子式 | C20H34O5 |
| 稳定性 | ≥ 1 year |
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