Rp-8-pCPT-Cyclic GMPS (sodium salt)
货号：
18445-1mg 基本售价：
3150.0 元 规格：
1 mg
产品信息
概述| 货号 | 18445-1mg |
| 描述 | Rp-8-pCPT-Cyclic GMPS is a stable, cell-permeable cGMP analog that competitively inhibits cGMP-dependent protein kinases (cGKs), including cGK Iα and cGK II (IC50s = 18.3 and 0.16 µM, respectively).1 The pCPT (p-chlorophenylthio) group at the 8-position of the purine increases both enzyme affinity and membrane permeability over related compounds.2 At 10 µM, it blocks the relaxation of rat tail arteries induced by the nitric oxide donor SIN-1 (Item No. 82220).3 |
| 别名 | Rp-8-pCPT-cGMPS; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gamm, D.M.,Francis, S.H.,Angelotti, T.P., et al. The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. The Journal of Biological Chemisty 270(45), 27380-27388 (1995).
2.Kramer, R.H., and Tibbs, G.R. Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action. Journal of Neuroscience 16(4), 1285-1293 (1996).
3.Ouedraogo, S.,Tschöp, M.,Stoclet, J.C., et al. Effects of cyclic GMP and analogues on neurogenic transmission in the rat tail artery. British Journal of Pharmacology 112, 867-872 (1994).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 525.9 |
| 分子式 | C16H14ClN5O6PS2 • Na |
| CAS号 | 208445-07-2 |
| 稳定性 | ≥ 2 years |
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