Dimethylamino Parthenolide
货号：
20436-25mg 基本售价：
3122.0 元 规格：
25 mg
产品信息
概述| 货号 | 20436-25mg |
| 描述 | Dimethylamino parthenolide (DMAPT) is a water-soluble parthenolide (Item No. 70080) analog developed for improved bioavailability.1 It has been shown to eradicate primary leukemia stem cells and to inhibit the proliferation and metastasis of various tumor cells by targeting NF-κB, generating reactive oxygen species, and decreasing metalloproteinases 2 and 9 as well as VEGF.1,2,3 |
| 别名 | DMAPT; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Guzman, M.L.,Rossi, R.M.,Neelakantan, S., et al. An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. Blood 110(13), 4427-4435 (2007).
2.DAnneo, A.,Carlisi, D.,Lauricella, M., et al. Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer. Cell Death Dis. 4(e891), (2013).
3.Song, J.M.,Qian, X.,Upadhyayya, P., et al. Dimethylaminoparthenolide, a water soluble parthenolide, suppresses lung tumorigenesis through down-regulating the STAT3 signaling pathway. Curr.Cancer Drug Targets 14(1), 59-69 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 293.4 |
| 分子式 | C17H27NO3 |
| CAS号 | 870677-05-7 |
| 稳定性 | ≥ 2 years |
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