| 货号 | 6058/10 |
| 供应商 | Tocris |
| 生物活性 | α5β1 integrin receptor antagonist. Reduces liver metastasis and improves survival in combination with 5-FU (Cat. No. 3257) in a mouse model of colon cancer. Reduces MLL tumor growth in rats and decreases tumor volume of human MDA-MB-231 cell xenografts in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 597.65 |
| 分子式 | C23H35N9O8 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | PHSCN (Modifications: Pro-1 = N-terminal Ac, Asn-5 = C-terminal amide) |
| 参考文献 | Khaliliet al (2006) A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol.Cancer Ther. 5 2271. PMID: 16985061. Stoeltzinget al (2003) Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int.J.Cancer. 104 496. PMID: 12584749. Livantet al (2000) Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma. Cancer Res. 60 309. PMID: 10667582. |