| 货号 | 4136/500U |
| 供应商 | Tocris |
| 生物活性 | NR2B-selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC50 = 480 nM); also inhibits NMDA-evoked responses in oocytes expressing N2RB, but not NR2A, subunits (IC50 ~300 nM). Exhibits neuroprotective properties in vivoandin vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 2264.21 |
| 分子式 | C88H138N26O4 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | GEXXLQXNQXLIRXKSN (Modifications: X = Gla, Asn-17 = C-terminal amide) |
| 参考文献 | Bushet al (2000) Selective antagonism of nigral neuropeptide responses to methamphetamine by conantokin G, a naturally occurring conopeptide. Eur.J.Pharmacol. 387 55. PMID: 10633160. Donevan and McCabe (2000) Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol.Pharmacol. 58 614. PMID: 10953056. Williamset al (2000) Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J.Pharmacol.Exp.Ther. 294 378. PMID: 10871336. |