Ro 5-3335 (10 MG)
货号:
4694/10 基本售价:
3113.1 元 规格:
10 mg
产品信息
概述货号 | 4694/10 |
别名 | 7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one; CBFβ-Runx1 inhibitor II |
性能供应商 | Tocris |
生物活性 | Core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Reduces leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. Also a Tat antagonist; inhibits HIV-1 replication in vitro. |
运输条件 | Blue Ice |
存放说明 | 4℃ |
纯度 | >98 % |
计算分子量 | 259.63 |
分子式 | C13H10ClN3O |
可溶性/溶解性 | Soluble to 100 mM in DMSO |
参考文献 | Cunninghamet al (2012) Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBF |