| 货号 | 3226/1 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1154.37 |
| 分子式 | C58H83N13O12 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| CAS号 | 229030-05-1 |
| 序列号 | KRPPGFSXI (Modifications: Lys-1 = N-terminal Ac, Phe-6 = (αMe)Phe, X = DβNal) |
| 参考文献 | Dukaet al (2003) Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. Hypertension 42 1021. PMID: 14557281. Gobeilet al (1998) Kinin B1 receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities. Hypertension 33823. Gobeilet al (1996) Structure-activity studies of B1 receptor related peptide. Hypertension 28 833. PMID: 8901831. |