| 货号 | 4665/100U |
| 供应商 | Tocris |
| 生物活性 | Selective CaV3.1 channel blocker (IC50 values are 0.2 and 31.8 μM for hCaV3.1 and hCaV3.2 respectively). Also reversibly inhibits NaV1.8 and blocks KV2.1 channels. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 3987.51 |
| 分子式 | C171H245N53O |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | ECRYWLGGCSAGQTCCKHLVCSRRHGWCVW (Modifications: Disulfide bridge: 2-16, 9-21, 15-28) |
| 参考文献 | Ohkubo and Yamazaki (2012) T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells. Int.J.Oncol. 41 267. PMID: 22469755. Ohkuboet al (2010) Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ channels Cav3.1 and Cav3.2. J.Pharmacol.Sci. 112 452. PMID: 20351484. Middletonet al (2002) Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry 41 14734. PMID: 12475222. |