| 货号 | 2080/1 |
| 供应商 | Tocris |
| 生物活性 | Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insulin secretion. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 2985.44 |
| 分子式 | C135H214N34O40S |
| 可溶性/溶解性 | Soluble to 1 mg/ml in 5% acetonitrile / water |
| CAS号 | 118025-43-7 |
| 序列号 | HADGVFTSDFSKLLGQLSAKKYLESLM (Modifications: Met-27 = C-terminal amide) |
| 参考文献 | Maet al (2004) Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem.Pharmacol. 67 1279. PMID: 15013843. Katoet al (1994) Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic β cells. J.Biol.Chem. 269 21223. PMID: 8063743. Itohet al (1983) Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature 304 547. PMID: 6571696. |