| 货号 | 1118/1 |
| 供应商 | Tocris |
| 生物活性 | An endogenous peptide derived from the same precursor as nociceptin, which is able to block nociceptin-induced allodynia and hyperalgesia and may play an opposing role in pain transmission. Shown to reverse nociceptin inhibition of glutamate release from rat brain slices; also modulates 5-HT transmission in the mouse neocortex via mechanisms separate from nociceptin/orphanin FQ. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1927.07 |
| 分子式 | C82H135N21O32 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in PBS |
| CAS号 | 208253-85-4 |
| 序列号 | TEPGLEEVGEIEQKQLQ |
| 参考文献 | Fantinet al (2007) Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic Gi/o protein linked pathways. Br.J.Pharmacol. 152 549. PMID: 17618307. Yamamotoet al (1999) Effect of nocistatin and its interaction with nociceptin/orphanin FQ on the rat formalin test. Neurosci.Lett. 262 179. PMID: 10218885. Nicolet al (1998) Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices. Eur.J.Pharmacol. 356 R1. PMID: 9774260. Okuda-Ashitakaet al (1998) Nocistatin, a peptide that blocks nociceptin action in pain transmission. Nature 392 286. PMID: 9521323. |