| 货号 | 4320/1 |
| 供应商 | Tocris |
| 生物活性 | CXCR4 antagonist (IC50 = 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50 = 21 nM for both strains). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 729.84 |
| 分子式 | C36H47N11O6< |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | XGYRR (Modifications: Cyclic peptide, X = 2-Nal, Tyr-3 = D-Tyr] |
| 参考文献 | Inokuchiet al (2011) Potent CXCR4 antagonists containing amidine type peptide bond isosteres. ACS Med.Chem.Lett. 2477. Tamamuraet al (2005) Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131 J.Med.Chem. 48 380. PMID: 15658852. |