| 货号 | 4646/10 |
| 别名 | N-[4-[2-(3,4-Dihydro-6,7-dimethoxy- |
| 供应商 | Tocris |
| 生物活性 | P-glycoprotein (P-gp/ABCG1) inhibitor. Blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin (Cat. No. 2252) and vincristine (Cat. No. 1257) in CHRC5 cells. Also inhibits breast cancer resistance protein (BCRP/ABCG2). Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 600.1 |
| 分子式 | C34H33N3O5 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Myeret al (1999) The chemosensitizing potential of GF120918 is independent of the magnitude of P-glycoprotein-mediated resistance to conventional chemotherapeutic agents in a small cell lung cancer line. Oncol Rep. 6 217. PMID: 9864431. Hyafilet al(1993)In vitroandin vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative. Cancer Res. 53 4595. PMID: 8402633. |