| 货号 | 2585/1 |
| 供应商 | Tocris |
| 生物活性 | Complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in baboons. Control peptide available (Cat. No. 3796). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1550.77 |
| 分子式 | C66H99N23O17S2 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| CAS号 | 206645-99-0 |
| 序列号 | ICVVQDWGHHRCT (Modifications: Thr-13 = C-terminal amide, Disulfide bridge between 2 - 12) |
| 参考文献 | Soulikaet al (2000) Inhibition of heparin/protamine complex-induced complement activation by compstatin in baboons. Clin.Immunol. 96 212. PMID: 10964539. Fianeet al (1999) Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation 6 52. PMID: 10355733. Sahuet al (1996) Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J.Immunol. 157 884. PMID: 8752942. |