| 货号 | 2177/1 |
| 供应商 | Tocris |
| 生物活性 | Highly selective NPY Y1 receptor antagonist. Ki values are 25.7, 1420, 2403 and 7100 nM at Y1, Y2, Y4 and Y5 receptors respectively. Devoid of agonist activity at Y4receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1221.46 |
| 分子式 | C58H92N16O13 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 262418-00-8 |
| 序列号 | INPIYRLRY (Modifications: Tyr-9 = Tyr-OMe) |
| 参考文献 | Joiset al (2006) Modeling of neuropeptide receptors Y1, Y4, Y5, and docking studies with neuropeptide antagonist. J.Biomol.Struct.Dyn. 23 497. PMID: 16494499. Jois and Balasubramaniam (2003) Conformation of neuropeptide Y receptor antagonists: structural implications in receptor selectivity. Peptides 24 1035. PMID: 14499282. Balasubramaniamet al (2001) Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro30, Tyr32, Leu34]NPY(28-36)-NH2 (BW1911U90). J.Med.Chem. 44 1479. PMID: 11334558. |