| 货号 | 4580/10 |
| 别名 | N,N-Diethyl-8,8-dipropyl-2-azaspiro |
| 供应商 | Tocris |
| 生物活性 | JAK2 inhibitor (IC50 = 397 nM). Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2V617Fmutation. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 409.52 |
| 分子式 | C22H44N2.2HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 10 mM in DMSO with gentle warming |
| 参考文献 | Manshouriet al (2011) Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer Res. 71 3831. PMID: 21512135. Quint |