| 货号 | 2067/1 |
| 供应商 | Tocris |
| 生物活性 | Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1784.13 |
| 分子式 | C96H122N18O16 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| CAS号 | 380488-27-7 |
| 序列号 | KFPFFPQ KFPFFPQ (Modifications: Phe-2 = D-Phe, Pro-3 = D-Pro, Phe-4 = D-Phe, Pro-6 = D-Pro, Cyclized) |
| 参考文献 | Prehoda and Lim (2002) How signaling proteins integrate multiple inputs: a comparison of N-WASP and cdk2. Curr.Opin.Cell Biol. 14 149. PMID: 11891112. Petersonet al (2001) A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc.Natl.Acad.Sci.USA 9810624. Suetsuguet al (2001) Identification of another actin-related (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J.Biol.Chem. 276 33175. PMID: 11432863. |