| 货号 | 1566/1 |
| 供应商 | Tocris |
| 生物活性 | Highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ,κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotropic and feeding stimulation effects in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1399.6 |
| 分子式 | C61H99FN22O15 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| CAS号 | 380620-88-2 |
| 序列号 | FGGFTGARKSARK (Modifications: Phe-4 = p-fluoro-Phe, Lys-14 = C-terminal amide) |
| 参考文献 | Bigoniet al (2002) Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies. Naunyn Schmiedebergs Arch.Pharmacol. 365 442. PMID: 12070757. Rizziet al (2002) Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 2. In vivo studies. Naunyn Schmiedebergs Arch.Pharmacol. 365 450. PMID: 12070758. Guerriniet al (2001) Structure-activity studies of the Phe4 residue of nociceptin(1-13)-NH2: Identification of highly potent agonists of the nociceptin/orphanin FQ receptor. J.Med.Chem. 44 3956. PMID: 11689082. |