| 货号 | 6090/1 |
| 别名 | NPQ, Neuropeptide Q |
| 供应商 | Tocris |
| 生物活性 | Potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Attenuates LH secretion in goldfish. Exhibits anxiolytic effects in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1619.9 |
| 分子式 | C74H114N20O1 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | NWTPQAMLYLKGAQ (Modifications: Gln-14 = C-terminal amide) |
| 参考文献 | Reyes-Alcarazet al (2016) Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice. Sci.Rep. 6 21453. PMID: 26907960. Kimet al (2014) Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology 155 1864. PMID: 24517231. Walewskiet al (2014) Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity Obesity (Silver Spring) 22 1643. PMID: 24550067. |