| 货号 | 3804/10 |
| 别名 | 1,3-Dihydro-1-[2-hydroxy-5-(trifluo |
| 供应商 | Tocris |
| 生物活性 | Large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 362.23 |
| 分子式 | C15H8F6N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 153587-01-0 |
| 参考文献 | Hanet al (2008) The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. Biochem.Biophys.Res.Comm. 375205. Debskaet al (2003) Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochem.Pharmacol. 65 1827. PMID: 12781334. Olesenet al (1994) Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone. Eur.J.Pharmacol. 251 53. PMID: 8137869. |