| 货号 | 3922/10 |
| 别名 | 3-(4-Chlorophenyl)-4-[[[(4-chloroph |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 630.44 |
| 分子式 | C27H25Cl2N7O7 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 412960-54-4 |
| 参考文献 | Aletrariet al (2011) Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways. PLoS One 6 e22713. PMID: 21799938. Crosset al (2009) Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum. J.Cell Science 1224393. Wanget al (2008) Inhibition of p97-dependent protein degradation by eeyarestatin I. J.Biol.Chem. 283 7445. PMID: 18199748. Wanget al (2008) ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc.Natl.Acad.Sci.USA 1062200. |