| 货号 | 4500/500U |
| 别名 | (9aS)-8-Acetyl-9,9a-dihydro-1,3,7-t |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro. Also inhibits Pkc1. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >96 % |
| 计算分子量 | 331.28 |
| 分子式 | C16H13NO7 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Houet al (2012) Targeting Mnks for cancer therapy. Oncotarget 3 118. PMID: 22392765. Koniceket al (2011) Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. Cancer Res. 71 1849. PMID: 21233335. Sussmanet al (2004) Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Eukaryot.Cell 3 932. PMID: 15302826. |