| 货号 | 5940/10U |
| 别名 | ρ-Da1a |
| 供应商 | Tocris |
| 生物活性 | Selective, high affinity, non-competitive α1A adrenoceptor antagonist (Ki = 0.35 nM). Exhibits no significant activity against a range of other GPCRs, including α2A,β1andβ2 adrenoceptors . Antagonizes effects of phenylephrine (Cat. No. 2838) on isolated rabbit prostate muscle in vitro and on intra-urethral pressure in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 7283.22 |
| 分子式 | C310H481N87O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | LTCVTSKSIFGITTEDCPDGQNLCFKRRHY (Modifications: Disulfide bridge: 3-24, 17-42, 46-57, 58-63) |
| 参考文献 | Paleaet al (2013) Effects of ρ-Da1a a peptidic α1A-adrenoceptor antagonist in human isolated prostatic adenoma and anaesthetized rats. Br.J.Pharmacol. 168 618. PMID: 23005263. Quintonet al (2010) Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the α1A-adrenoceptor. Br.J.Pharmacol. 159 316. PMID: 20015090. |