| 货号 | 2549/1 |
| 别名 | z-Pseudosubstrate inhibitory peptide |
| 供应商 | Tocris |
| 生物活性 | Novel, cell-permeable inhibitor of protein kinase Mζ(PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Control and biotinylated peptides (Cat. Nos. 3215 and 3290) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1982.4 |
| 分子式 | C90H154N30O17 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 863987-12-6 |
| 序列号 | SIYRRGARRWRKL (Modifications: Ser-1 = Myr-Ser) |
| 参考文献 | Pastalkovaet al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141. PMID: 16931766. Serranoet al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979. PMID: 15728837. Linget al (2002) Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci. 5295. |