| 货号 | 4639/1 |
| 供应商 | Tocris |
| 生物活性 | Peptide agonist for sst1/sst4 somatostatin receptors. Somatostatin analog; inhibits tyrosine kinase activity in human colon tumor cell lines. Demonstrates an antiproliferative effect both in vitroandin vivo and induces apoptosis in a pancreatic tumor cell line. Does not inhibit growth hormone release or secretion. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 947.13 |
| 分子式 | C45H58N10O9< |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | fCYwKCT (Modifications: Disulfide bridge between 2 - 6; Thr-7 = C-terminal amide) |
| 参考文献 | Elekeset al (2008) Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse. Eur.J.Pharmacol. 578 313. PMID: 17961545. Tejedaet al (2006) Evaluation of the antitumor efficacy of the somatostatin structural derivative TT-232 on different tumor models. Anticancer Res. 26 3477. PMID: 17094470. Kériet al (1996) A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 93 12513. PMID: 8901613. |