| 货号 | 3497/5 |
| 别名 | Thrombin receptor activator peptide 6 |
| 供应商 | Tocris |
| 生物活性 | Peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. Stimulates platelet aggregation (EC50 = 0.8 μM), promotes intracellular Ca2+ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 748.88 |
| 分子式 | C34H56N10O9 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 141136-83-6 |
| 序列号 | SFLLRN |
| 参考文献 | Hunteret al (2009) Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets. J.Biol.Chem. 284 12339. PMID: 19261611. Kaufmannet al (1999) PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells. J.Neurooncol. 42 131. PMID: 10421070. Vassalloet al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides. J.Biol.Chem. 267 6081. PMID: 1313429. |