| 货号 | 2476/10 |
| 别名 | (E,E,Z,E)-3-Methyl-7-(4-methylpheny |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, RARγ and RXRα). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 376.54 |
| 分子式 | C26H32O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| CAS号 | 160162-42-5 |
| 参考文献 | Shioharaet al (1999) Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro. Blood 93 2057. PMID: 10068679. Huanget al (1997) Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc.Natl.Acad.Sci.USA 945826. Fanjulet al (1994) A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 372 107. PMID: 7969403. |