| 货号 | 3230/1 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 975.11 |
| 分子式 | C47H66N12O11 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | XRPPGFSPF (Modifications: X = Sar, Phe-9 = D-Phe) |
| 参考文献 | Leeb-Lundberget al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27. PMID: 15734727. Drapeauet al (1993) Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 266 192. PMID: 8392550. Drapeauet al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 259 997. PMID: 1662280. |