货号 | 2999/10 |
别名 | 4-[4-(4-Fluorophenyl)-1-(3-phenylpr |
供应商 | Tocris |
生物活性 | Selective p38α and p38β inhibitor (IC50 values are 1 and 11 μM respectively) that displays no activity at p38γ, p38δ and a range of other kinases. Potently inhibits TNF-α and IL-1β release (IC50 values are 3 and 11 nM respectively) and suppresses HIV-1 replication in T cells in vitro. Displays cardioprotective and anti-inflammatory activity in vivo. Orally active. |
运输条件 | Blue Ice |
存放说明 | Ambient |
纯度 | >98 % |
计算分子量 | 425.5 |
分子式 | C27H24FN3O |
可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
CAS号 | 215303-72-3 |
参考文献 | Muthumaniet al (2004) Suppresssion of HIV-1 viral replication and cellular pathogenesis by a novel p38/JNK kinase inhibitor. AIDS 18 739. PMID: 15075508. Seeet al (2004) p38 mitogen activated protein kinase inhibition improves cardiac function and attenuates left ventricular remodeling fowllowing myocardial infarction in the rat. J.Am.Coll.Cardiol. 44 1679. PMID: 15489104. Wadsworthet al (1999) RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. J.Pharm.Exp.Ther. 291680. |