| 货号 | 2517/10 |
| 别名 | 6-Methyl-1'-[2-(5-methyl-2-phenyl-4- |
| 供应商 | Tocris |
| 生物活性 | Extremely selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 417.5 |
| 分子式 | C25H27N3O3 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 300816-15-3 |
| 参考文献 | Kitagawaet al (2004) Blockade of CCR2 ameliorates progressive fibrosis in kidney. Am.J.Pathol. 165 237. PMID: 15215179. Furuichiet al (2003) CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J.Am.Soc.Nephrol. 14 2503. PMID: 14514728. Mirzadeganet al (2000) Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists. J.Biol.Chem. 275 25562. PMID: 10770925. |