| 货号 | 1587/1 |
| 别名 | 3-[(8S)-8-[(Dimethylamino)methyl]-6 |
| 供应商 | Tocris |
| 生物活性 | Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α,βΙ,βΙΙ,γandε respectively. Orally available and prevents T cell chronic inflammation in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 489.01 |
| 分子式 | C28H28N4O2.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO with gentle warming |
| CAS号 | 151342-35-7 |
| 参考文献 | Birchallet al (1994) Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J.Pharmacol.Exp.Ther. 268 922. PMID: 8114006. Wilkinsonet al (1993) Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem.J. 294 335. PMID: 8373348. |