| 货号 | 4045/5 |
| 别名 | N-[(Phenylmethoxy)carbonyl]-L-isole |
| 供应商 | Tocris |
| 生物活性 | Proteasome inhibitor; inhibits chymotrypsin-like activity of the proteasome. Causes dopaminergic cell death in vitro. Prevents activation of NF-κB in response to TNF-α and okadaic acid (Cat. No. 1136) by inhibiting IκB-α degradation. Also inhibits NO production by LPS-activated macrophages. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >90 % |
| 计算分子量 | 618.77 |
| 分子式 | C32H50N4O8 |
| 可溶性/溶解性 | Soluble to 30 mM in DMSO |
| CAS号 | 158442-41-2 |
| 参考文献 | Bukhatwaet al (2009) An immunohistochemical and stereological analysis of PSI-induced nigral neuronal degeneration in the rat. J.Neurochem. 109 52. PMID: 19187437. Griscavageet al (1996) Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB. Proc.Natl.Acad.Sci.USA 933308. Traenckneret al (1994) A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB. EMBO J. 13 5433. PMID: 7957109. |