| 货号 | 3092/10 |
| 别名 | N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl- |
| 供应商 | Tocris |
| 生物活性 | Potentα7 nAChR agonist that displays selectivity over α3β4,α1β1γδ,α4β2 and 5-HT3 receptors. Positively influences sensory gating and memory in in vivo models of schizophrenia. Orally active and brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 307.78 |
| 分子式 | C15H17N3O2.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 25 mM in DMSO |
| CAS号 | 478149-53-0 |
| 参考文献 | Ackeret al (2008) Discovery of N-[3R,5R)-1-azabicyclo[3.2.1]ocy-3-yl]furo-[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: in vitro and in vivo activity. Bioorg.Med.Chem.Letts. 183611. Faghihet al (2008) Allosteric modulators of the α7 nicotinic acetylcholine receptor. J.Med.Chem. 51 701. PMID: 18198823. Wishkaet al (2006) Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia; synthesis and structure-activity relationship. J.Med.Chem. 49 4425. PMID: 16821801. |