| 货号 | 3117/10 |
| 别名 | (2R,3R,4R,5S)-1-Butyl-2-(hydroxymet |
| 供应商 | Tocris |
| 生物活性 | Orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 255.74 |
| 分子式 | C10H21NO4 |
| 可溶性/溶解性 | Soluble to 75 mM in water and to 75 mM in DMSO |
| CAS号 | 210110-90-0 |
| 参考文献 | Noelet al (2008) Parallel improvements of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells. J.Pharamcol.Exp.Ther. 3251016. Dweket al (2002) Targeting glycosylation as a therapeutic approach. Nat.Rev.Drug Disc. 165. Plattet al(1994)N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J.Biol.Chem. 269 8362. PMID: 8132559. |